If you work out of your home and your home is your principal place of business, you can generally deduct the cost of traveling from home to any business destination. This is true whether the destination is another regular place of business, a temporary place of business (such as a client or project location), or a destination such as a bank, post office, supplier, etc.

 

If you are a real estate agent and you maintain your principal place of business in your home, you can deduct the expenses that you incur in traveling between your home and the houses you're trying to sell.

Whether your home is your principal place of business is determined under the same standards that apply to home office deductions. If your home doesn't qualify as your principal place of business, you must follow the general rules in determining whether a particular car trip is sufficiently business-related to be deductible.